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Nature Communications 7:11190

Connecting to other gene-expression datasets Using GSEA, sets of genes reported to change with COPD-related phenotypes or with TGF treatment in other gene-expression studies were examined in a ranked list of genes ordered from most induced in severe emphysema to most repressed in severe emphysema by the t-statistic of the Lm coefficient in the linear mixed-effects model

In the past, the Schilling test was used, but is rarely conducted today because this test uses radioactive B12

In patients with renal dysfunction, peak concentrations of metabolites 4'-hydroxy- and 5-hydroxy-diclofenac were approximately 50% and 4% of the parent compound after single oral dosing compared to 27% and 1% in normal healthy subjects