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Caspase-1 activation has been observed in experimental rat models of rhabdomyolysis,34 whereas the use of ferroptosis inhibitors in these rats reduced cell death of proximal tubules.49 Lastly, the accumulation of haemoproteins and their derivatives may induce autophagy as a defence mechanism.46,50,51 Fibrosis Renal fibrosis is another mechanism involved in renal damage caused by haemoproteins

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The procedure typically involves inserting a needle or trocar through soft tissue to obtain a bone sample for pathology review

The activation of vitamin D3 occurs in the liver, while further processing to calcitriol occurs in the kidney