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The two-receptor approach is studied because GHRH and GHS-R1a signaling activate complementary but distinct intracellular pathways GHRHR primarily through Gs/cAMP/PKA, GHS-R1a primarily through Gq/PLC/IP3/Ca making the dual-agonist approach a useful research tool for studying somatotrope cell biology comprehensively

Science 310 , 11931196 (2005)

In the cerebro-cerebellar loop, chained GABAergic neurons (Basket cells and PCs) determine the phasic command on timing and synergy (see the GABA-Mediated Disinhibition/Inhibition Mode for Online Predictive Controls section) for coordination [34], with specific emphasis on the exact timing of GABA release

Brain accessibility delineates the central effects of circulating ghrelin