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*Correspondence: Chi Wang Ip, [email protected] This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

It has normal catalytic activity and is not associated with hemolysis (Class IV)

The more fluid the person drinks, the greater the volume of urine excreted

Clearly, the human HsaGST A3-3 and the equine EcaGST A3-3 stand out as the enzymes with the most prominent ketosteroid isomerase activities, but also HsaGST A1-1, the porcine SscGST A2-2, and the marmoset CjaGST A3-3 have high intrinsic activities with 5-AD