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Get Tested and Consult with a Doctor Medical attention may be needed to obtain further treatment if the chills and rigors are without fever, recurring, or even if they are coupled with other symptoms

The latter enrolled 190 patients with obesity (mean age 54.4 years, mean BMI 36.1 kg/m 2 ) and biopsy-proven MASH and moderate-to-severe fibrosis regardless of the presence of T2D, showing a BW reduction of 10.7%, 13.3%, 15.6% and 0.8% at 52 weeks with tirzepatide 5 mg, 10 mg, 15 mg and placebo, respectively 39

In addition, participants were required to abstain from using inhibitors for transporters P-gp, BCRP, OAT1, OAT3, MATE1, and MATE2-K during the study