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Yearbook of Intensive Care and Emergency Medicine 99 LazzarinoG.ListortiI.BilottaG.CapozzoloT.AmoriniA

The liver is the principal site for the hydroxylation of cholecalciferol at carbon 25 by 25-hydroxylase enzymes (CYP2R1 and CYP27A1) to form 25(OH)VD 3