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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]

Rarely reported symptoms associated with excessive B12 intake may include: Skin reactions : Acne-like eruptions or rosacea-type dermatitis have been occasionally reported, particularly with high-dose intramuscular injections Gastrointestinal disturbance : Mild nausea, diarrhoea, or abdominal discomfort, though these are uncommon Headache : Infrequent reports of headaches following parenteral B12 administration Hypersensitivity reactions : In very rare cases, allergic reactions to injectable B12 preparations have been documented It is crucial to note that there is no established link between standard B12 supplementation and serious adverse effects

This distinction matters not because B12 injections are inherently dangerous, but because the systems surrounding the injection determine how quickly and effectively a provider can respond if something unexpected occurs

Retatrutide is an investigational peptide drug currently under clinical development by Eli Lilly