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To test whether GSTF11 and GSTU20 also play synergistic functions in GSL biosynthesis, we constructed gstf11 and gstu20 double mutant (Supplementary Figure 6)

It is a dimeric complex composed of: The calcitonin receptor (CTR) , a GPCR The RAMP protein (Receptor Activity Modifying Protein), 1, 2 or 3 Depending on the type of RAMP, three different amylin receptors arise: AMY1 : CTR + RAMP1, primarily in the CNS (area postrema, hypothalamus) AMY2 : CTR + RAMP2, peripheral tissues AMY3 : CTR + RAMP3, bone tissue, some CNS Cagrilintide activates all three amylin receptors , but the primary therapeutic effect is via AMY1 in the area postrema (brainstem, where nausea and satiety signals are processed)

J Trace Elem Med Biol 38:7480 Ashour A, Cameron P, Bernard S, Fitzgerald M, Smith K, Walker T (2007) Could bystander first-aid prevent trauma deaths at the scene of injury