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It contributes to increased levels within the body itself

de Boer TN, van Spil WE, Huisman AM, et al

For example, after coated with a silica layer, the zinc dioxide (ZnO) NPs exhibited less cytotoxicity in human dermal fibroblast cells with less enzyme leakage, ROS production, and oxidative stress than their bare NPs, as a result of the surface modification restricting formation of free radicals and the release rate of zinc ions, as well as reducing the surface interactions of ZnO NPs with cells (Ramasamy et al., 2014)

Contributing Factors While mites play a central role in mange development, several contributing factors can exacerbate the condition or increase susceptibility: Poor hygiene and sanitation create an environment conducive to mite infestation