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We noted in the CY 2019 PFS final rule (83 FR 59851) that bonus points were created as transition policies, which were not meant to continue through the life of the program

2 Takaoka et al stated that the expression of estrogen receptor (ER) in ovarian endometrial stromal cells (OESCs) was suppressed at the gene and protein levels after DRIAs treatment, which in turn inhibited the expression of COX-2 and the production of PGE2

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