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Work from our and other groups showed that LAC also modulates acetylation of NF-B/p65 subunit, which potentiates the transcriptional activity of NF-B member to increase transcription of the Grm2 gene encoding for the mGlu2 receptor in hippocampus and prefrontal cortex of FSL rats [30, 36]

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A microfiltered fraction enriched with lactosylceramide (44.3%) was shown to induce caspase-independent cell death, indicated by externalization of phosphatidylserine, elevated DNA fragmentation, and a reduction in mitochondrial membrane potential in SW480 cells

However, all imaging features were initially reviewed independently by two experienced subspecialty radiologists, with discrepancies resolved by a third expert adjudicating discordant cases