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Bulk RNA-seq on WT, WT treated with H 2 O 2 (WT + H 2 O 2 ), and GPX2 KO spontaneously differentiated DE cells revealed distinct transcriptional profiles among all samples with KO and WT + H 2 O 2 clustering more closely to each other than to WT (Supplementary Fig

doi: 10.1093/gbe/evy062 165 ZhuK.GeD.WenZ.XiaL.YangQ

This decrease in GSH weakens the body's antioxidant capacity, making hepatocytes more susceptible to damage from oxidative stress [38] [1]

Intra-macrophage growth, cell-to-cell spread, and virulence in vivo were proportionally rescued with constitutive overexpression trans-complementation of ptsI (Fig 4C and 4D)