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These cells then undergo final maturation into terminally differentiated antibody producing plasma cells in secondary lymphoid organs such as the spleen and lymph nodes ( Figure 1 ) ( Figure 1 B cells are stimulated either by T cell independent or dependent mechanisms, both of which are now known to create distinct metabolic dependencies ( et al , recently showed B cells stimulated with LPS displayed a progressive upregulation of tricarboxylic acid (TCA) cycle and electron transport chain (ETC) genes to support increased oxidative phosphorylation (OXPHOS) ( BLIMP1