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Eur J Mol Clin Med (2020) 7(1):321323

Phase II metabolism When legume polyphenols bypass small intestinal absorption, they are transformed by the colonic microbiota into smaller phenolic metabolites, such as phenylpropionic, phenylacetic, and benzoic acid derivatives (Aura, 2008

Drug Interactions The methionine metabolite S-adenosyl methionine (SAM) may interact with antidepressants, antipsychotics, amphetamines, and narcotics causing excess accumulation of serotonin in the body