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In addition to calcium overload, most PD-related genes, such as a-synuclein, PINK1, Parkin, LRRK2, DJ-1, GBA and ATPA13A2, are involved in mitochondrial function and autophagy-lysosome pathways, and mutations in these genes cause diverse alterations related to the progression of PD [12, 13]

Of the 14, clusters 1 and 4 expressed -cell markers ( Ins1, Ins2 ) (Fig

Enzyme-linked immunosorbent assay (ELISA) The concentration of PCSK6 in the cell culture supernatants were determined using a relevant PCSK6 ELISA kit (Innovative Research, Vancouver, Canada)

Because of its ability to promote new blood vessel growth and cell migration, it can also enhance recovery in areas with poor circulation or chronic injury