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The two subunits are differentiated in red and blue in the Figure below

These symptoms most often include: Paresthesia: Numbness, itching, burning, or tingling in the limbs or other parts of the body Ataxia: impaired coordination, balance, and speech Myelopathy: pain in the neck or back and tingling, numbness, or weakness in the limbs The occurrence of these conditions in people with vitamin B12 deficiency is due to the role of vitamin B12 in preventing nerve damage and ensuring efficient transmission of nerve impulses

Nat Rev Drug Discov 22:8388 Narayanan IG, Natarajan SK (2018) Peptides derived from histidine and methionine-rich regions of copper transporter 1 exhibit anti-angiogenic property by chelating extracellular Cu

In fact, they not only complement one anothers functions but also support each other