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Supplement & Nutritional Therapy Supplements to prevent muscle cramps with the best evidence include: Magnesium glycinate or citrate most effective for nocturnal leg cramps, toe cramps, and whole-body spasms related to electrolyte imbalance Potassium particularly valuable for leg cramps at night and charley horses in athletes Vitamin D3 + K2 addresses deficiency-related myofascial pain and muscle weakness Vitamin B12 important for nerve health

In addition, objective measures of cognition and attention will be needed to further assess the impact of NAC on these symptoms in MS patients

Falk JL

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