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With a molecular weight of 45 kDa, holoTC is readily filtered through the renal glomeruli, and then re-internalized by multiple receptor-dependent endocytic processes (via the megalin/cubilin/amnionless receptor complex) (57, 58)

Such pro-inflammatory vascular effect may promote adhesion of monocytes to endothelial cells, a crucial event in the early atherosclerotic process [105]

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Commenters stated that making this flexibility permanent would significantly expand access to care, especially for patients living in rural regions, racial or ethnic minorities, tribal populations, individuals for whom English is a secondary language, older Medicare beneficiaries, and dual enrollees in Medicare and Medicaid