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ASC/overlap can be differentiated from typical AIH by a lesser female predisposition, high serum alkaline phosphatase to aspartate aminotransferase (AST) ratio, presence of peri-nuclear anti-neutrophil cytoplasmic antibodies (p-ANCA), stronger association with inflammatory bowel disease (IBD), and a worse prognosis than typical AIH

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Hence its popularity in skin creams, serums and lotions, all meant for topical application

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