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Removal of the dysfunctional proteins, organelles, and cells is necessary for preserving cellular homeostasis, and this is achieved by the processes of autophagy and programmed cell death, including apoptosis

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Integration and expression of the transgene were more robust in mice with MMA compared with treated wild-type animals, demonstrating a selective growth advantage over unedited MMUT-deficient hepatocytes

Reports of clinical benefit of plitidepsin (Aplidine), a new marine-derived anticancer agent, in patients with advanced medullary thyroid carcinoma