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TQ acts as a peroxisome proliferator-activated receptor gamma ( PPAR - ) antagonist, which can improve insulin resistance and inhibit intestinal glucosidase, the latter of which leads to reduced glucose absorption

Due to its methylation by a catecholamine O-methyl transferase (COMT), levodopa is administered in conjunction with COMT inhibitors such as entacapone, tolcapone, and benzaseride [9]

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When the drug is given as an infusion, metabolism and elimination become important because all compartments would be equilibrated