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Furthermore, T0901317, an LXR agonist, restored LXR signalling, cholesterol efflux, and improved inflammation as reflected by reduced levels of IL-6 (-25%), TNFA (-75%), and NFkB1 (-50%)

Equal amounts of protein lysates were resolved by sodium dodecyl sulfate -polyacrylamide gel electrophoresis and were transferred to polyvinylidene difluoride membranes

As it has been previously stated, DNMTs and TETs are essential for the methylation of DNA, but they fulfill important roles for normal hematopoiesis as well

The iPSC-derived neurons with A3243G mutation and various tissues derived from teratomas showed cell-type specific respiratory chain deficiency patterns, with differentiated neurons showing defective mitochondrial complex activity and mitophagy (Klein Gunnewiek et al., 2020)