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While in many mammalian species UA is further degraded to allantoin, in humans and certain other primates the uricase activity responsible for this metabolic removal has been lost

The abundance of folate biosynthetic genes in human colon microbiome may change with the age 262,263,264

(2) poor antioxidant defense due to endogenous glutathione deficiency as a result of decreased biosynthesis and/or increased depletion of GSH is the most probable cause of increased oxidative damage of the lung, regardless which of the factors aging, chronic disease comorbidity, smoking or some others were responsible for this deficit." As Polonikov writes 22 and Seheult describes in the video, oxidative damage from reactive oxygen species (ROS) plays a significant role in severe disease with COVID-19

[53] Moore KL, et al