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Triple agonism at GIP, GLP-1 and glucagon receptors in a single molecule Body-weight and energy-balance endpoints (rapidly expanding 20252026 research literature) Glucagon-receptor engagement that sets it apart from single- and dual-agonist compounds Benchmarked against Semaglutide and Tirzepatide in comparative research Areas of laboratory and preclinical research only

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While confirming the on-target drug effect, we observed this sensitivity in both galunisertib or vactosertib-treated HGC27-derived subcutaneous tumors in vivo and in patient-derived GC organoid cultures with intact TGF signaling components in vitro (Fig