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Long-term exposure to the anti-inflammatory agent phenylbutazone induces kidney tumors in rats and liver tumors in mice

Earlier studies indicate that abnormal activation of the HGF/c-MET signaling pathway may hinder T-cell activation and growth, adversely affect DCs, and enhance the infiltration of immunosuppressive cells (M2-type TAMs, MDSCs, and Tregs), leading to reduced effectiveness of ICIs

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Peptides with hydrophobic motifs interact well with the lipid components of cell membranes, aiding their ability to penetrate cells 56