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The enzyme has been identified in a number of higher plants, algae and cyanobacteria (reviewed in Caverzan et al., Arabidopsis thaliana , the reported eight isoenzymes of APX can be categorized into three groups: soluble cytosolic (APX1, APX2, and APX6), (Dbrowska et al., 2002) (Table 2)

Glossary AP-1 Activator Protein 1 ARDS Acute respiratory distress syndrome ARE Antioxidant response element ART Artesunate ASC Apoptosis-associated speck-like protein containing a CARD BALB/c A common laboratory mouse strain Bcl-2 B-cell lymphoma 2 BEAS-2B Bronchial Epithelial Cells Cov Coronavirus COVID-19 Coronavirus Disease 2019 CXCL C-X-C Motif Chemokine Ligand Cy-3-G Cyanidin-3-glucoside DNA Deoxyribonucleic Acid ERK Extracellular signal-regulated kinase GSP Grape seed proanthocyanidins H1N1 Hemagglutinin Type 1 and Neuraminidase Type 1 Influenza A Virus HO-1 Heme Oxygenase-1 IAV Influenza A Virus IKK IB kinase IL-6 Interleukin-6 IRF3 Interferon Regulatory Factor 3 IB Inhibitor of kappa B J774A.1 A murine macrophage cell line JUK C-Jun N-terminal Kinase signaling pathway Keap1 Kelch-like ECH-associated protein 1 MAPK Mitogen-Activated Protein Kinase MDCK Madin-Darby Canine Kidney cells mtDNA Mitochondrial DNA mTOR Mechanistic target of rapamycin mtROS Mitochondrial ROS NADPH Reduced Nicotinamide Adenine Dinucleotide Phosphate NF-B Nuclear Factor kappa-light-chain-enhancer of activated B cells NLRP3 NOD-like receptor family pyrin domain containing 3 NOD1 NAD(P)H Quinone Dehydrogenase 1 Nrf2 Nuclear factor erythroid 2related factor 2 P38 P38 Mitogen-Activated Protein Kinase p65 RelA (part of NF-B) PA Patchouli alcohol PAMPs Pathogen-associated molecular patterns PI3K/Akt Phosphoinositide 3-kinase/Protein Kinase B Pn-3-G Peonidin-3-glucoside RIG Retinoic acid-Inducible Gene RNA Ribonucleic Acid RNS Reactive nitrogen species ROS reactive oxygen species RSV Respiratory syncytial virus SARS Severe Acute Respiratory Syndrome TCM Traditional Chinese Medicine TF2b Theaflavin-3-gallate THP-1 Human monocytic leukemia cell line TLRs Toll-Like Receptors TNF- Tumor necrosis factor-alpha References 1 ArjsriP.SrisawadK.MapoungS.SemmarathW.ThippraphanP.UmsumarngS.et al (2022)

This result suggests a potential association between these two phenomena

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