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Description

Safety and translational challenges are considerable and must drive clinical application: immune stimulation carries theoretical risk as well as known risk of worsening autoimmune phenomena or inflammatory toxicities, particularly in the setting of active immunosuppression (e.g., newly diagnosed with cytotoxic therapy, on high-dose steroids)

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[DOI] [PMC free article] [PubMed] [Google Scholar] (507).Nabhan JF

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doi: ..10.1056/NEJMoa022536 [PubMed: 12890843] [CrossRef] 288

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Wells that appeared to have improved stability were regrown and tested under the same conditions

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