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Virtually all endothelial cells lining sinusoids in the central regions had abnormal shapes, and some of them appeared to be disrupted (Table 2

It is believed that reactive oxygen species (ROS) play a key role in the dermal extracellular matrix alterations that are intrinsic to aging and photoaging

Body weight and food intake were measured 2 and 5 days before dosing, and 1, 2, 3, 5, 7, 10, 12, and 21 days after dosing