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The degeneration of neurons producing dopamine in the substantia nigra leads to a depletion of dopamine within the striatum, disrupting the finely tuned excitatory and inhibitory signaling in the basal ganglia

Springer, Heidelberg, pp 4572 Lange SC, Bak LK, Waagepetersen HS, Schousboe A, Norenberg MD (2012) Primary cultures of astrocytes: their value in understanding astrocytes in health and disease