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GH pulses are exquisitely sensitive to insulin: a carbohydrate or high-fat meal drives insulin up, and elevated insulin suppresses GH release almost immediately, so a dose taken on top of a recent meal is partly wasted

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In a study published in The Journal of Clinical Endocrinology & Metabolism , Tesamorelin elevated IGF-1 levels within 2 weeks of administration, confirming its efficacy in stimulating GH pathways (Gelato et al., 2004)