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Group for the Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and European League Against Rheumatism (EULAR) have both proposed recommendations for management of PsA that identify situations in which TNF inhibitor therapy is appropriate (Figure 6-2)

Dietary deficiency: Strict vegans or very poor diets may lack animal-source B12

Mouse model of periventricular leukomalacia A model of neonatal brain injury, which reliably resembles the neuropathology of PVL, 19, 20 was induced in P6 mouse pups using ischemia induced by unilateral carotid ligation (UCL) and followed by hypoxia, which resulted in selective injury to the periventricular white matter