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IOC is a leading cause of mortality in individuals with chronic anemia-related disorders, such as -thalassemia and SCD, who undergo long-term transfusions, affecting approximately 2.5% of chronically transfusion-dependent SCD patients [19, 36, 41]

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The C3a-treated mice had also higher density of excitatory synapses and higher expression of the membrane phosphoprotein growth-associated protein 43 467 , which is an established marker of axonal sprouting and plasticity 468,469