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Genetics 150, 533542

Sphingolipids as modulators of SARS-CoV-2 infection

Peptide mechanisms: Signal fibroblasts to produce more collagen (signal peptides) Inhibit muscle contractions that cause expression lines (neurotransmitter peptides like Argireline) Deliver copper to enhance healing and collagen synthesis (carrier peptides like GHK-Cu) Protect against oxidative damage and inflammation (antioxidant peptides) Timeline for results: 4-8 weeks: Improved hydration and texture 8-12 weeks: Noticeable firmness improvement 3-6 months: Visible reduction in wrinkles and fine lines Advantage: Peptides rarely cause irritation

70 found that 0.52% of subjects had signs of HPP based on subnormal ALP activity and elevated PLP laboratory values