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Cycling recommendations are less established due to the early stage of human research, but the general principle of periodic breaks applies

The functional GO enrichment analysis on 71 hypermethylated genes depicted 11 GO-biological terms, with the top three overexpressed gene clusters including the regulation of ARF protein signal transduction (MAP4K4, IQSEC1, IQSEC3), response to fluid shear stress (AKT1, ACE, SOCS5) and antigen processing and presentation of peptide antigen via MHC class 1 (ACE, MICB, SAR1B) (Fig

FreeSurfer regional segmentation was then performed on the unbiased template image, and the hippocampal formation mask was generated by binarizing and combining the labels corresponding to the hippocampus and the entorhinal cortex, while an extended hippocampal formation mask was additionally generated to also include the parahippocampal cortex