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5, PP 989-994 [online] Available at: (accessed 7 th April 2022) Gao, X., Sanderson, S.M., Dai, Z., Reid, M.A., Cooper, D.E., Lu, M., Richie, J.P., Ciccarella, A., Calcagnotto, A., Mikhael, P.G., Mentch, S.J., Liu, J., Ables, G., Kirsch, D.G., Hsu, D.S., Nichenametia, S.N

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Immunohistochemical staining for MMP13, ADAMTS5, and Collagen II in the articular cartilage showed that metformin treatment significantly reduced the MIA-induced upregulation of MMP13 and ADAMTS5, while increasing Collagen II synthesis in the articular chondrocytes (Fig