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In this work, GSH-CDs was demonstrated as an effective candidate for delaying disc degeneration, which effectively improves the conditions of malignant oxidative stress within the NPCs microenvironment in a multiple cascade-like activities manner, that is, inhibits the senescence of NPCs induced by excessive accumulated ROS via exerting multiple antioxidant enzyme activity

These findings suggest that targeting Sphk1 could offer a promising approach for preventing and treating ICH-related neurodegeneration

Ethics declarations Competing interests Sung-Il Yun and Seung Sik Lim are employees of Bioneer Corporation

Lentivirus-AIMP2-DX2 shRNA suppresses cell proliferation by regulating Akt1 signaling pathway in the lungs of AIMP2(+)/() mice