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Mitochondrial function is required for extracellular ATP-induced NLRP3= inflammasome activation

regulates tumor necrosis factor (TNF) and IL6 production posttranscriptionally by phosphorylating AUrich elements (AREs)binding proteins ELAVL1, HNRNPA0, PABPC1, and TTP/ZFP36, leading to increased stability and translation of TNF and IL6 mRNAs

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After a year of dogs being fed the Purina recipe or a control diet, the researchers reported that:"In conclusion, a specially formulated diet [Purina Pro Plan CC Cardiocare dry food] was not associated with significant changes in LAD [left atrium dimension] and LVIDd [left ventricle dimension] when fed to dogs with mild subclinical DMVD for 1 year as compared to control diet."In other words, Purina Pro Plan CC Cardiocare dry food was no better than plain old kibble in treating MVD