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Antibody concentrations showed a median concentration reduction of 69% (range 27%99%), and decrease was over 25% in 15 of the 17 serum samples after immunotherapy (figure 5)

Abstract Renal proximal tubular cells are high energy-demanding cells mainly relying on fatty acid oxidation

This leads to mitochondrial dysfunction, a shift in cell energy utilization from high-efficiency oxidation to low-efficiency glycolysis, reduced basic energy consumption, and increased susceptibility to obesity (92)