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The results of cross-sectional studies of subclinical vascular disease show that higher homocysteine concentrations are associated with greater carotid artery intimal-medial wall thickness (Malinow et al, 1993

In rats with acute myocardial ischemiareperfusion injury, elevated plasma Hcy induced mitochondrial dysfunction and oxidative stress through increased cytochrome c release, stimulation of ROS production, and ERK1/2 signaling pathway that subsequently caused cardiac dysfunction [66]

3.2 Methods of administration and therapeutic potential Improving semen quality with antioxidants is a well-researched approach that targets one of the key causes of male infertility: oxidative stress

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