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81 (or 9%) of the 889 genes on the microarray chip designated as intermediary metabolism and respiration were upregulated, while 56 (or 6%) were downregulated, by up to approximately 26-fold and approximately 4-fold, respectively (Sikri et al., 2015)

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Les lsions de l'ADN activent les PARP, qui peuvent consommer jusqu' 90 % du NAD+ cellulaire, ce qui rend la rparation de l'ADN fortement dpendante de la disponibilit du NAD+

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