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The following diagram should serve to illustrate this

The NRTI 3-deoxy-3-fluorothymidine ( alovudine or FLT), known for its high toxicity, can cause DNA fragmentation and induce apoptosis (Sundseth et al., 1996)

Arwert LI, Deijen JB, Drent ML

Conversely, the downregulation of sirtuin 6 (SIRT6) in hepatoma cells enables TGF-1/ROS to induce cell senescence, counteracting its tumorigenic effects [112]