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Moreover, a unique point mutation of PSMB5 (gene encoding the proteasome 5 subunit) alleviates fatal ER stress, promoting bortezomib resistance in MM cells (122)

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This schematic highlights how curcumin disrupts key inflammatory cascades such as the IKK/NF-B pathway, shifts immune cell phenotypes toward anti-inflammatory states, suppresses the expression of pro-fibrotic factors such as TGF- and CTGF, and promotes the apoptosis of inflammatory cells

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