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Heritable variants in different urate transporters also affect serum urate responses to dietary challenges such as fructose and potentially some medications, but with mixed results for diuretics

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For instance, in one 1960s study of intravenous NAD+ for addiction, patients who received a fast IV drip experienced immediate headache and shortness of breath, whereas those given the same dose at a slower drip rate (under ~35 drops/min) had no distress

1) Oxidative block irreversible, makes NADPH and CO Step 1: G6P + NADP 6-phosphogluconolactone + NADPH via G6PD (rate-limiting) Step 2: lactone + HO 6-phosphogluconate Step 3: 6-PG + NADP ribulose-5-P (Ru5P) + CO + NADPH Net per G6P: 2 NADPH + CO + Ru5P 2) Non-oxidative block reversible sugar shuffling Ru5P ribose-5-P (R5P) or xylulose-5-P (Xu5P) Transketolase (TPP-dependent) moves 2-carbon pieces: Xu5P + R5P sedoheptulose-7-P + GAP