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In their 2018 study, a combination of curcumin (500 mg/day) and piperine significantly reduced C-peptide, HbA1c, and glucose levels, while their 2017 study indicated that higher doses of curcumin (1,000 mg) with piperine increased adiponectin levels, reduced leptin levels, and improved the leptin/adiponectin ratio (Panahi et al., 2017)

de Guglielmo G, Kallupi M, Scuppa G, Stopponi S, Demopulos G, Gaitanaris G, Ciccocioppo R (2014) Analgesic tolerance to morphine is regulated by PPAR

For all these mutants, the maximum growth rate was defined as the objective function, and FBA, along with pFBA, was performed to calculate the optimal flux distributions across the metabolic network