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For the treatment of depression, osteoarthritis, and liver conditions, SAM has been studied when taken orally or intravenously

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J Steroid Biochem Mol Biol 155:2634 Gourlaouen M, Welti JC, Vasudev NS, Reynolds AR (2013) Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells