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Therefore, the intestine serves as a barrier tissue whereby a monolayer of intestinal epithelial cells establishes a multilayered physicochemical barrier ( The mucosal barrier also includes mucin, antimicrobial peptides, and dimeric (or more polymeric) IgA secreted by goblet cells, Paneth cells, and plasma cells, respectively ( Altered microbial composition, termed dysbiosis, has been implicated in mucosal barrier dysfunction and inflammatory responses, which predispose the host animals to systemic diseases (e.g., inflammatory bowel disease, celiac disease, food allergy, obesity, and autoimmune diseases) ( Table 1 )

Neuroendocrine Rebalancing Central GLP-1 receptor activation modulates hypothalamic circuits related to energy and reproductive signaling, including interactions with kisspeptin and gonadotropin neurons

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Additionally, WZBSF can protect granulosa cells, restore follicle numbers at various stages, and reduce the extent of follicular atresia [61]