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A significant proportion of tested samples have exceeded safety thresholds for endotoxin contamination, which refers to bacterial byproducts that, when injected, trigger systemic inflammation or, in serious cases, septic shock

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Muscles that have not been reconnected to nerves within 18 months of injury weaken to the point where re-innervation may no longer be possible

Though dose-related embryotoxic, fetotoxic, and teratogenic effects were observed in most of these studies, particularly those on rats, maternal toxicity was not adequately assessed or reported in any of these investigations