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246 Sepsis often triggers a sepsis-associated encephalopathy (SAE) which presents itself with wide symptomatology including reduced attention, disrupted sleep-wakefulness balance, impaired speech and orientation, deficient leaning and memory, numerous perception disorders, focal neurological deficits, seizures, and, in terminal stages, coma

adults who tolerate it for at least four weeks may increase to a maximum 7.2 mg when additional weight reduction is clinically indicated

If NAC is not provided within 8 hours after APAP intoxication, plasma GST levels will keep increasing and at 4050 hours will be correlated with the time when the major liver damage occurs [48]