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Beyond QT syndromes, catecholaminergic polymorphic ventricular tachycardia (CPVT) models carrying RYR2 or CASQ2 mutations show spontaneous Ca waves and DADs under adrenergic stimulation, ameliorated by dantrolene or gene therapy 19,109 , and Brugada syndrome ( SCN5A ) models display reduced sodium currents, impaired conduction, and phase 2 reentry-like abnormalities 110

IS-mediated AHR binds to NF-B p65 subunit and leads to mutual inhibition of AHR and NF-B, which suppresses the production of TNF- in macrophages of CKD patients