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doi: 10.1016/j.it.2017.06.008 12 CrozatKGuitonRGuilliamsMHenriSBaranekTSchwartz-CornilIet al

10.1155/2022/3294273 Evid

In a related rat model, activation of p62/Nrf2 and downregulation of ROS were also observed, as evidenced by reductions in arthritis scores and pathological features (marked infiltration of inflammatory cells, synovial hyperplasia, cartilage damage and bone destruction), as well as inhibition of NFATc1 and other osteoclast activities and bone resorption regulators (CTSK and MMP-9)

Th1 cytokines such as IFN- , IL-2 and TNF- were also increased in the spleen of WT mice injected with Con A, whereas those were not increased in the spleen of Gpx1 KO mice injected with Con A (Figure 5b)